We are pleased to share the successful process development for the synthesis of trans-4-(bromomethyl)cyclohexane-1-carboxylic acid (CAS 1652586-30-5) — a versatile building block, synthetic intermediate, and linker with growing importance in medicinal and materials chemistry.

With both functional handles — bromomethyl (reactive site) and carboxylic acid (coupling anchor) — this molecule serves as a practical platform for new drug discovery and materials innovation.

Applications
• Drug discovery linker: Enables incorporation into complex molecular frameworks.
• Building block for advanced materials: Useful in MOF/COF design, polymer science, and specialty intermediates.

References
• Shibuya, K. et al., Discovery of the Clinical Candidate … [K-604], J. Med. Chem. 2018, 61, 10635–10650 

• Listed by BLD Pharm and AIF Chem as a precursor for MOF/COF linkers, polymer science, and functionalized cyclohexane derivatives.

We welcome collaborations, inquiries, and supply discussions.